Efficacy of novel haemogram parameters in the evaluation of inflammation in acute ischemic stroke

Authors

  • Isıl Yazıcı Gencdal Bakırköy Mazhar Osman Educational and Research Hospital
  • Banu Bayramoglu University of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Educational and Research Hospital, Department of Neurology
  • Buket Sahin Artvin State Hospital
  • Kürsat Nuri Baydili University of Health Sciences, Hamidiye Faculty of Medicine, Department of Biostatistics and Medical Informatics
  • Aysu Sen University of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Educational and Research Hospital, Department of Neurology
  • Dilek Ataklı versity of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Educational and Research Hospital, Department of Neurology
  • Aysun Soysal versity of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Educational and Research Hospital, Department of Neurology

DOI:

https://doi.org/10.54029/2024yxm

Keywords:

stroke, immature granulocyte,, inflammation, systemic immune-inflammation index

Abstract

Objective: Inflammation in ischemic brain tissue is the primary factor contributing to the pathogenesis of acute ischemic stroke (AIS). This study aimed to investigate the role of new inflammatory parameters—immature granulocyte count (IGc) and the systemic immune-inflammation index (SII)—in determining the presence of inflammation and the subtype, severity, and prognosis of AIS.

Methods: This retrospective study was conducted using data from 124 patients with AIS and 126 healthy controls. The severity at stroke onset and the functional outcome after at least 3 months of follow- up were determined. Patients with AIS were subdivided into subgroups according to aetiology. The following haemogram parameters were compared between the AIS and control groups: haemogram parameters; white blood cell (WBC) count, haemoglobin (Hgb), haematocrit (HCT), mean platelet volume (MPV), platelet count (PLT), PCT (plateletcrit), lymphocyte and neutrophil count, RDW-CV (red cell distribution width coefficient of variation), neutrophil/lymphocyte ratio (NLR), MPV/PLT ratio, PLT/lymphocyte ratio (PLR), WBC/MPV ratio (WMR), IGc and IG percentage (IG%), and SII values.

Results: The parameters WBC, IGc, IG%, RDWCV, neutrophil count, NLR, WMR, and SII values were significantly higher in the AIS group than in the control group. We found significant correlations between high SII value and high clinical NIHSS scores at stroke onset, mRS obtained after at least a 3-month follow-up period.

Conclusion: IGc and SII may be new parameters to evaluate the presence of inflammation in patients with AIS. A higher SII was associated with higher stroke severity, and it may be useful for predicting adverse clinical outcomes.

Published

2024-12-25

Issue

Section

Original Article