Study on the changes in blood biochemical indicators of patients with Cerebral venous sinus thrombosis and their correlation with imaging examination results

Abstract

Objective: This study investigates the implications of combining blood biochemical indicators with imaging for Cerebral venous sinus thrombosis (CVST) diagnosis, aiming to enhance diagnostic precision and speed.

Methods: We retrospectivity analyzed data from 120 CVST patients between August 1, 2016, and July 31, 2023, examining clinical, laboratory, and cranial MRI and MRV imaging data. Statistical methods assessed the diagnostic significance of various blood indicators and their correlation with CVST.

Results: Headache was the most common symptom, followed by changes in vision, epileptic seizures, and neurological deficits. D-dimer levels, fibrinogen, plateletcrit, mean corpuscular volume (MCV) and platelet distribution width were higher in CVST patients compared to controls. Subgroup analysis revealed that gender and age might influence certain blood test indicators. Notably, a significant difference in D-dimer levels between patient groups with and without complications was observed, suggesting its potential as a biomarker for complication risk. Logistic regression model analysis further confirmed the significant positive correlation between elevated D-dimer levels and CVST risk, also noting that increases in plateletcrit and platelet distribution width were positively correlated with CVST risk. Moreover, through correlation analysis using point biserial correlation coefficient and Spearman’s correlation coefficient, significant correlations were found among blood test indicators, and between these indicators and CVST status. MRI and MRV, as key imaging tools for diagnosing CVST, directly display thrombus formation, further enhancing diagnostic accuracy.

Conclusion: Blood biochemical markers and imaging (MRI and MRV) are vital in diagnosing CVST, aiding in faster, accurate clinical decision-making and better patient outcomes.