Evaluation of systemic immune and inflammatory biomarkers in pediatric idiopathic intracranial hypertension patients
DOI:
https://doi.org/10.54029/2025kreKeywords:
idiopathic intracranial hypertension, monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response indexAbstract
Background & Objective: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure with normal cerebrospinal fluid analysis and neuroimaging findings. The aim of this study is to evaluate the relationship between systemic immune-inflammation index (SII) (neutrophil*platelet/lymphocyte count) and systemic inflammation response index (SIRI) (monocyte*neutrophil/lymphocyte count) as inflammatory markers with IIH in pediatric patients.
Methods: A total of 42 eyes from 21 pediatric patients diagnosed with IIH and 42 eyes from 21 control subjects were included in the study. Macular and peripapillary measurements, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), SII, and SIRI were recorded.
Results: The study included groups matched for age and gender. When comparing inflammatory parameters, significantly higher values were observed in individuals with IIH for NLR (P < 0.001), PLR (P = 0.005), SII (P < 0.001), and SIRI (P < 0.016). In the univariate analysis of inflammatory parameters, NLR, PLR, MLR, SII, and SIRI values were identified as potential markers for IIH (P = 0.001, P < 0.001, P = 0.004, P = 0.004, P = 0.001, respectively). In the multivariate logistic regression analysis, NLR and PLR values were significantly higher (NLR: OR=3.8, 95% confidence interval [CI]: 1.3-11.0, P=0.013; PLR: OR=6.0, 95% CI: 1.7-20.8, P=0.005). Significant differences were found in mean retinal nerve fiber layer thickness (RNFLT) values between the two groups on OCT (p<0.001). Significant differences were also detected in ganglion cell layer thickness values between the two groups (p=0.003).
Conclusion: Multivariate logistic regression analysis suggests that NLR and PLR values could be effectively used in the diagnosis and treatment of the disease. No statistically significant differences were found between groups in SII and SIRI values.
