Authors
					
											- 
							
								Yaping Huang
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
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								Yun Chen
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
- 
							
								Yan Wu
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
- 
							
								Yan Wu
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
- 
							
								XinYi Dai
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
- 
							
								Juan Feng
							
															
									Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
																				
- 
							
								Xia Li
							
															
									Peking university Shougang Hospital
																	
																				
										Keywords:
				
				
											acute ischemic stroke, 											lipid profiles, 											thrombolysis, 											symptomatic intracerebral hemorrhage, 											meta-analysis									
			
			
										
					Abstract
					Objective: This meta-analysis aims to evaluate the association between lipid profiles and the risk of symptomatic intracerebral hemorrhage (sICH) when using thrombolysis to treat acute ischemic stroke (AIS).
Methods: We included 11 studies from various geographic regions, focusing on patients treated with intravenous thrombolysis. Lipid parameters such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglycerides were examined.
Results: While no discernible correlation was found between total cholesterol levels and sICH risk, two studies reported significantly lower LDL levels in patients with sICH. Additionally, lower HDL levels and elevated triglycerides correlated with increased sICH risk in specific studies.
Conclusion: These findings highlight the complex role of lipid profiles in stroke management, particularly in the context of thrombolytic therapy. Sensitivity analyses validated the robustness of the findings, suggesting that lipid management strategies should be individualized for AIS patients to balance ischemic and hemorrhagic risks. Future large-scale randomized trials are warranted to validate these findings.
				
			
			
																																																																																																																							
					
													Author Biographies
											
																		
								
																																							Yaping Huang, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									Yaping Huang, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
								 
							
																								
								
																																							Yun Chen, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									Yun Chen, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China.
								 
							
																								
								
																																							Yan Wu, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									Yan Wu, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China.
								 
							
																								
								
																																							Yan Wu, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									Yan Wu, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China.
								 
							
																								
								
																																							XinYi Dai, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									XInyi Dai, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China。
								 
							
																								
								
																																							Juan Feng, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China
																	
								
									Juan Feng, Department of Neurology, Peking university shougang hospital, Beijing, 100043,China.